Annual report pursuant to Section 13 and 15(d)

Debt (Details Textual)

v3.10.0.1
Debt (Details Textual) - USD ($)
1 Months Ended 12 Months Ended
May 07, 2018
Mar. 13, 2018
Aug. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Oct. 11, 2018
Jun. 01, 2017
Jan. 30, 2017
Dec. 31, 2016
May 29, 2015
Nov. 30, 2012
Debt Instrument [Line Items]                      
Gain (Loss) on Extinguishment of Debt       $ (1,706,000) $ (182,000)            
Amortization of Debt Discount (Premium)       $ 254,000 $ 824,000            
Debt Instrument, Fee Amount $ 200,000                    
Common Stock Purchased By Warrants Issued       75,000              
Common Stock, Par or Stated Value Per Share       $ 0.001 $ 0.001 $ 0.001          
Class of Warrant or Right, Exercise Price of Warrants or Rights       $ 55.138     $ 4.70       $ 55.10
Derivative Liability       $ 156,000 $ 130,000       $ 20,000    
Discontinued Operations [Member]                      
Debt Instrument [Line Items]                      
Amortization of Debt Discount (Premium)       178,000 577,000            
Warrant [Member]                      
Debt Instrument [Line Items]                      
Derivative Liability       2,700,000              
Perceptive Credit Holdings LP [Member]                      
Debt Instrument [Line Items]                      
Extinguishment of Debt, Amount $ 14,800,000                    
Repayments of Debt       $ 14,800,000              
Bridge Loan [Member]                      
Debt Instrument [Line Items]                      
Debt Instrument, Face Amount   $ 2,000,000           $ 400,000 $ 1,000,000    
Debt Instrument, Interest Rate Terms   The BLN bore interest at a rate per annum equal to the sum of (i) the greater of (x) LIBOR and (y) 1%, plus (ii) an applicable margin of 9.75%.                  
Upfront Fee Payable   $ 250,000                  
Senior Secured Debt [Member]                      
Debt Instrument [Line Items]                      
Debt Instrument, Face Amount                   $ 15,500,000  
Proceeds from Divestiture of Businesses and Interests in Affiliates     $ 1,650,000                
Repayments of Debt     1,618,000                
Payments For Prepayment Penalties     $ 32,000                
Write off of Deferred Debt Issuance Cost         53,000            
Prepayment Penalty On Early Extinguishment Of Debt         32,000            
Amortization of Debt Discount (Premium)         $ 129,000